A | B | C | D | E | F | G | H | CH | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9
| Glutamate—methylamine ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.3.4.12 | ||||||||
| CAS no. | 37318-69-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a glutamate—methylamine ligase (EC 6.3.4.12) is an enzyme that catalyzes the chemical reaction
- ATP + L-glutamate + methylamine ADP + phosphate + N5-methyl-L-glutamine
The 3 substrates of this enzyme are ATP, L-glutamate, and methylamine, whereas its 3 products are ADP, phosphate, and N5-methyl-L-glutamine.
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is L-glutamate:methylamine ligase (ADP-forming). This enzyme is also called gamma-glutamylmethylamide synthetase.
References
- Kung HF, Wagner C (1969). "Gamma-glutamylmethylamide. A new intermediate in the metabolism of methylamine". J. Biol. Chem. 244 (15): 4136–40. PMID 5800436.
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