Inositol monophosphatase 1 - Wiki slovník

IMPA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AWB, 1IMA, 1IMB, 1IMC, 1IMD, 1IME, 1IMF, 2HHM, 4AS4
Identifiers
Aliases	IMPA1, IMP, IMPA, inositol monophosphatase 1, MRT59
External IDs	OMIM: 602064; MGI: 1933158; HomoloGene: 4043; GeneCards: IMPA1; OMA:IMPA1 - orthologs
EC number	3.1.3.94
Gene location (Human)
Chr.	Chromosome 8 (human)
End	81,686,331 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	10,396,499 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; jejunal mucosa; ; endothelial cell; ; mucosa of colon; ; tibia; ; mucosa of sigmoid colon; ; right ventricle; ; Brodmann area 23; ; Epithelium of choroid plexus; ; bronchial epithelial cell;
	Top expressed in
	motor neuron; ; ciliary body; ; retinal pigment epithelium; ; iris; ; Paneth cell; ; facial motor nucleus; ; conjunctival fornix; ; external carotid artery; ; Epithelium of choroid plexus; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inositol monophosphate phosphatase activity; manganese ion binding; protein homodimerization activity; metal ion binding; lithium ion binding; protein binding; identical protein binding; hydrolase activity; magnesium ion binding; inositol monophosphate 1-phosphatase activity; inositol monophosphate 4-phosphatase activity; inositol monophosphate 3-phosphatase activity;
Cellular component	cytoplasm; cytosol;
Biological process	inositol metabolic process; inositol biosynthetic process; inositol phosphate metabolic process; phosphatidylinositol phosphate biosynthetic process; phosphate-containing compound metabolic process; phosphatidylinositol biosynthetic process; signal transduction; inositol phosphate dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	3612
	55980
	ENSG00000133731
	ENSMUSG00000027531
	P29218
	O55023
	NM_005536; NM_001144878; NM_001144879
	NM_018864; NM_001310433
	NP_001138350; NP_001138351; NP_005527
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Inositol monophosphatase 1 is an enzyme that in humans is encoded by the IMPA1 gene.^[5]^[6]

Interacting partners

IMPA1 has been shown to interact with Bergmann glial S100B^[7] and calbindin.^[8]^[9]

Chemical inhibitors

L-690,330 is a competitive inhibitor of IMPase activity with very good activity in vitro however with limited bioavailability in vivo.^[10] Due to its increased specificity compared to Lithium, L-690,330 has been used extensively in characterizing the results of IMPase inhibition in various cell culture models. L-690,488, a prodrug or L-690,330, has also been developed which has greater cell permeability. Treatment of cortical slices with L-690,488 resulted in accumulation of inositol demonstrating the activity of this inhibitor in tissue.^[11]

Inhibition of IMPA1 activity can have pleiotropic effects on cellular function, including altering phosphoinositide signalling,^[12] autophagy, apoptosis,^[13] and other effects.

Bipolar disorder

Initially it was noticed that several drugs useful in treatment of bipolar disorder such as lithium, carbamazepine and valproic acid had a common mechanism of action on enzymes in the phosphatidylinositol signalling pathway^[14] and the inositol depletion hypothesis for the pathophysiology of bipolar disorder was suggested. Intensive research has so far not confirmed this hypothesis, partly because lithium can also act on a number of other enzymes in this pathway, complicating results from in vitro studies.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133731 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027531 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McAllister G, Whiting P, Hammond EA, Knowles MR, Atack JR, Bailey FJ, Maigetter R, Ragan CI (Aug 1992). "cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme". Biochem J. 284 (3): 749–54. doi:10.1042/bj2840749. PMC 1132602. PMID 1377913.
^ "Entrez Gene: IMPA1 inositol(myo)-1(or 4)-monophosphatase 1".
^ Vig PJ, Shao Q, Subramony SH, Lopez ME, Safaya E (September 2009). "Bergmann glial S100B activates myo-inositol monophosphatase 1 and Co-localizes to purkinje cell vacuoles in SCA1 transgenic mice". Cerebellum. 8 (3): 231–44. doi:10.1007/s12311-009-0125-5. PMC 3351107. PMID 19593677.
^ Schmidt H, Schwaller B, Eilers J (April 2005). "Calbindin D28k targets myo-inositol monophosphatase in spines and dendrites of cerebellar Purkinje neurons". Proc. Natl. Acad. Sci. U.S.A. 102 (16): 5850–5. Bibcode:2005PNAS..102.5850S. doi:10.1073/pnas.0407855102. PMC 556286. PMID 15809430.
^ Berggard T, Szczepankiewicz O, Thulin E, Linse S (November 2002). "Myo-inositol monophosphatase is an activated target of calbindin D28k". J. Biol. Chem. 277 (44): 41954–9. doi:10.1074/jbc.M203492200. PMID 12176979.
^ Atack JR, Cook SM, Watt AP, Fletcher SR, Ragan CI (February 1993). "In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330". J. Neurochem. 60 (2): 652–8. doi:10.1111/j.1471-4159.1993.tb03197.x. PMID 8380439. S2CID 23498954.
^ Atack JR, Prior AM, Fletcher SR, Quirk K, McKernan R, Ragan CI (July 1994). "Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers". J. Pharmacol. Exp. Ther. 270 (1): 70–6. PMID 8035344.
^ King JS, Teo R, Ryves J, Reddy JV, Peters O, Orabi B, Hoeller O, Williams RS, Harwood AJ (2009). "The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cells". Dis Models Mech. 2 (5–6): 306–12. doi:10.1242/dmm.001271. PMC 2675811. PMID 19383941.
^ Sarkar S, Rubinsztein DC (2006). "Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations". Autophagy. 2 (2): 132–4. doi:10.4161/auto.2387. PMID 16874097.
^ Williams RS, Cheng L, Mudge AW, Harwood AJ (May 2002). "A common mechanism of action for three mood-stabilizing drugs". Nature. 417 (6886): 292–5. Bibcode:2002Natur.417..292W. doi:10.1038/417292a. PMID 12015604. S2CID 4302048.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Inositol monophosphatase 1

Zdroj:https://en.wikipedia.org?pojem=Inositol_monophosphatase_1
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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133731 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027531 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1377913-5] McAllister G, Whiting P, Hammond EA, Knowles MR, Atack JR, Bailey FJ, Maigetter R, Ragan CI (Aug 1992). "cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme". Biochem J. 284 (3): 749–54. doi:10.1042/bj2840749. PMC 1132602. PMID 1377913.

[entrez-6] "Entrez Gene: IMPA1 inositol(myo)-1(or 4)-monophosphatase 1".

[pmid19593677-7] Vig PJ, Shao Q, Subramony SH, Lopez ME, Safaya E (September 2009). "Bergmann glial S100B activates myo-inositol monophosphatase 1 and Co-localizes to purkinje cell vacuoles in SCA1 transgenic mice". Cerebellum. 8 (3): 231–44. doi:10.1007/s12311-009-0125-5. PMC 3351107. PMID 19593677.

[pmid15809430-8] Schmidt H, Schwaller B, Eilers J (April 2005). "Calbindin D28k targets myo-inositol monophosphatase in spines and dendrites of cerebellar Purkinje neurons". Proc. Natl. Acad. Sci. U.S.A. 102 (16): 5850–5. Bibcode:2005PNAS..102.5850S. doi:10.1073/pnas.0407855102. PMC 556286. PMID 15809430.

[pmid12176979-9] Berggard T, Szczepankiewicz O, Thulin E, Linse S (November 2002). "Myo-inositol monophosphatase is an activated target of calbindin D28k". J. Biol. Chem. 277 (44): 41954–9. doi:10.1074/jbc.M203492200. PMID 12176979.

[pmid8380439-10] Atack JR, Cook SM, Watt AP, Fletcher SR, Ragan CI (February 1993). "In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330". J. Neurochem. 60 (2): 652–8. doi:10.1111/j.1471-4159.1993.tb03197.x. PMID 8380439. S2CID 23498954.

[pmid8035344-11] Atack JR, Prior AM, Fletcher SR, Quirk K, McKernan R, Ragan CI (July 1994). "Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers". J. Pharmacol. Exp. Ther. 270 (1): 70–6. PMID 8035344.

[pmid19383941-12] King JS, Teo R, Ryves J, Reddy JV, Peters O, Orabi B, Hoeller O, Williams RS, Harwood AJ (2009). "The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cells". Dis Models Mech. 2 (5–6): 306–12. doi:10.1242/dmm.001271. PMC 2675811. PMID 19383941.

[pmid16874097-13] Sarkar S, Rubinsztein DC (2006). "Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations". Autophagy. 2 (2): 132–4. doi:10.4161/auto.2387. PMID 16874097.

[pmid12015604-14] Williams RS, Cheng L, Mudge AW, Harwood AJ (May 2002). "A common mechanism of action for three mood-stabilizing drugs". Nature. 417 (6886): 292–5. Bibcode:2002Natur.417..292W. doi:10.1038/417292a. PMID 12015604. S2CID 4302048.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Interacting partners

Chemical inhibitors

Bipolar disorder

References

Further reading

External links