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Loxicodegol
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Names | |
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IUPAC name
(4R,4aS,7S,7aR,12bS)-9-methoxy-7-2-2-2-2-(2-methoxyethoxy)ethoxyethoxyethoxyethoxyethoxy-3-methyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro3,2-eisoquinolin-4a-ol
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Other names
Loxicodegol; NKTR-181
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Identifiers | |
3D model (JSmol)
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DrugBank | |
KEGG | |
PubChem CID
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UNII | |
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Properties | |
C31H49NO10 | |
Molar mass | 595.730 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C 77 °F, 100 kPa).
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Oxycodegol (also known as loxicodegol and NKTR-181) is an experimental μ-opioid receptor agonist for the treatment of pain.[1][2] It has had success for back pain as an alternative to traditional opioids,[3] which have potential for abuse. It acts more slowly on the central nervous system, reducing risk for abuse and respiratory depression.[1]
Referencesedit
- ^ a b Advokat, Claire D.; Comaty, Joseph E.; Julien, Robert M. (2019). Julien's Primer of Drug Action: a comprehensive guide to the actions, uses, and side effects of psychoactive drugs. New York: Worth Publishers. p. 565. ISBN 978-1-319-20054-1.
- ^ "NKTR-181 (Oxycodegol) Oral Tablets for. Chronic Low Back Pain". Food and Drug Administration. Archived from the original on 24 December 2020.
- ^ Markman, John; Gudin, Jeffrey; Rauck, Richard; Argoff, Charles; Rowbotham, Matthew; Agaiby, Eva; Gimbel, Joseph; Katz, Nathaniel; Doberstein, Stephen K; Tagliaferri, Mary; Lu, Lin; Saddhanti, Suresh; Hale, Martin (June 2019). "SUMMIT-07: a randomized trial of NKTR-181, a new molecular entity, full mu-opioid receptor agonist for chronic low-back pain". PAIN. 160 (6): 1374–1382. doi:10.1097/j.pain.0000000000001517. PMC 6553961. PMID 30747908.
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Chemical nomenclature
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PubChem
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Μ-opioid receptor
Agonist
Central nervous system
Worth Publishers
ISBN (identifier)
Special:BookSources/978-1-319-20054-1
Food and Drug Administration
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PMC (identifier)
PMID (identifier)
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Chemical nomenclature
CAS Registry Number
JSmol
DrugBank
IUPHAR/BPS
KEGG
PubChem
Unique Ingredient Identifier
International Chemical Identifier
Simplified molecular-input line-entry system
Chemical formula
Molar mass
Standard state
Wikipedia:Chemical infobox#References
Μ-opioid receptor
Agonist
Central nervous system
Worth Publishers
ISBN (identifier)
Special:BookSources/978-1-319-20054-1
Food and Drug Administration
Doi (identifier)
PMC (identifier)
PMID (identifier)
File:Paracetamol-3D-vdW.png
Analgesic
Wikipedia:Stub
Template:Analgesic-stub
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Special:EditPage/Template:Analgesic-stub
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