TAS2R40 - Wiki slovník

TAS2R40
Identifiers
Aliases	TAS2R40, GPR60, T2R40, T2R58, taste 2 receptor member 40
External IDs	OMIM: 613964; MGI: 2681312; HomoloGene: 47977; GeneCards: TAS2R40; OMA:TAS2R40 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	143,223,079 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	42,193,221 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; blood; ; white blood cell; ; monocyte; ; sural nerve; ; spleen; ; appendix; ; right lung; ; left uterine tube; ; upper lobe of lung;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; bitter taste receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	detection of chemical stimulus involved in sensory perception of bitter taste; signal transduction; response to stimulus; sensory perception of taste; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	259286
	387515
	ENSG00000221937
	ENSMUSG00000051917
	P59535
	Q7TQB8
	NM_176882
	NM_001001453
	NP_795363
	NP_001001453
	Wikidata
View/Edit Human	View/Edit Mouse

Taste receptor type 2 member 40 is a protein that in humans is encoded by the TAS2R40 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000221937 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051917 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (Oct 2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855. S2CID 20426192.
^ "Entrez Gene: TAS2R40 taste receptor, type 2, member 40".

Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982. S2CID 37807140.
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520. S2CID 718601.
Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.
Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.

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