Transcobalamin - Wiki slovník

transcobalamin II; macrocytic anemia
transcobalamin II; macrocytic anemia
Identifiers
Symbol	TCN2
NCBI gene	6948
HGNC	11653
OMIM	275350
PDB	2BB5
RefSeq	NM_000355
UniProt	P20062
Other data
Locus	Chr. 22 q11.2-qter
Structures
Search for
Structures	Swiss-model
Domains	InterPro

transcobalamin I (vitamin B₁₂ binding protein, R binder family)
transcobalamin I (vitamin B12 binding protein, R binder family)
Identifiers
Symbol	TCN1
NCBI gene	6947
HGNC	11652
OMIM	189905
RefSeq	NM_001062
UniProt	P20061
Other data
Locus	Chr. 11 q11-q12
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Transcobalamins are carrier proteins which bind cobalamin (B₁₂).

Types

Transcobalamin I (TCN1), also known as haptocorrin, R-factor, and R-protein, is a glycoprotein produced by the salivary glands of the mouth. It primarily serves to protect cobalamin (Vitamin B12) from acid degradation in the stomach by producing a Haptocorrin-Vitamin B12 complex. Once the complex has traveled to the more neutral duodenum, pancreatic proteases degrade haptocorrin, releasing free cobalamin, which now binds to intrinsic factor for absorption by ileal enterocytes.
Transcobalamin II (TCN2) binds cobalamin once it has been taken up by enterocytes of the terminal ileum and the "Intrinsic Factor-Vitamin B12" complex has been degraded. Transcobalamin II is then involved with the transport of Vitamin B12 to the tissues.^[1]

^ Rachmilewitz B, Rachmilewitz M, Chaouat M, Schlesinger M (July 1977). "The synthesis of transcobalamin II, a vitamin B12 transport protein, by stimulated mouse peritoneal macrophages". Biomédicine. 27 (6): 213–4. PMID 907799.

Transcobalamins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Zdroj:https://en.wikipedia.org?pojem=Transcobalamin
>Text je dostupný pod licencí Creative Commons Uveďte autora – Zachovejte licenci, případně za dalších podmínek. Podrobnosti naleznete na stránce Podmínky užití.

v t e Proteins: carrier proteins
Fatty acid	FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7
Hormone	peptide hormone: Follistatin Growth hormone binding protein Insulin-like growth factor binding protein IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 Neurophysins Neurophysin I II steroid hormone: Sex hormone binding globulin/Androgen binding protein Transcortin Thyroxine-binding globulin Transthyretin
Metal/element	calcium Calcium-binding protein Calmodulin-binding proteins copper Ceruloplasmin iron Iron-binding proteins Transferrin receptor
Vitamin	Retinol binding protein 1 2 3 4 Transcobalamin
Pigment	Plant Light-Harvesting Complex Orange Carotenoid Protein Phycobiliprotein Photosynthetic Reaction Centers Phytochrome Rhodopsin
Other	Acyl carrier protein Adaptor protein Cholesterylester transfer protein F-box protein GTP-binding protein Latent TGF-beta binding protein Major urinary proteins Membrane transport protein Odorant binding protein