This article does not cite any sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "Phthalylsulfathiazole" – news · newspapers · books · scholar · JSTOR (August 2014) (Learn how and when to remove this template message)

Phthalylsulfathiazole

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	A07AB02 (WHO)
Identifiers
IUPAC name 2-(1,3-Thiazol-2-ylamino)sulfonylphenyl}amino)carbonylbenzoic acid
CAS Number	85-73-4 N
PubChem CID	4806
ChemSpider	4641 N
UNII	6875L5852V
KEGG	D02440 Y
ChEMBL	ChEMBL1524273 N
CompTox Dashboard (EPA)	DTXSID8023470
ECHA InfoCard	100.001.480
Chemical and physical data
Formula	C17H13N3O5S2
Molar mass	403.43 g·mol−1
3D model (JSmol)	Interactive image
SMILES OC(=O)c1ccccc1C(=O)Nc2ccc(cc2)S(=O)(=O)Nc3nccs3 C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)/N=C\3/NC=CS3)C(=O)O
InChI InChI=1S/C17H13N3O5S2/c21-15(13-3-1-2-4-14(13)16(22)23)19-11-5-7-12(8-6-11)27(24,25)20-17-18-9-10-26-17/h1-10H,(H,18,20)(H,19,21)(H,22,23) N Key:PBMSWVPMRUJMPE-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Phthalylsulfathiazole (also known as sulfathalidine) belongs to the group of drugs called sulfonamides. The drug is a broad-spectrum antimicrobial that can treat different types of infections including intestinal. The mechanism of action depends on competitive antagonism with para-aminobenzoic acid and inhibition of dihydropteroate synthetase activity, which in turn leads to impaired synthesis of dihydrofolic acid and as a result its active metabolite necessary for the synthesis of purine and pyrimidine.

The drug is indicated in the treatment of dysentery, colitis, gastroenteritis and intestinal surgery. It is not absorbed into the blood stream from the gut due to extra n⁴ substitute. Adverse effects may include allergic reactions, vitamin B insufficiency, agranulocytosis and aplastic anemia.

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

• v
• t
• e